Transforming Growth Factor b1–Induced NADPH Oxidase-4 Expression and Fibrotic Response in Conjunctival Fibroblasts
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چکیده
Citation: Brown KD, Shah MH, Liu G-S, Chan EC, Crowston JG, Peshavariya HM. Transforming growth factor b1– induced NADPH oxidase-4 expression and fibrotic response in conjunctival fibroblasts. Invest Ophthalmol Vis Sci. 2017;58:3011–3017. DOI:10.1167/ iovs.16-20633 PURPOSE. Fibrotic scarring after ocular surgeries and chemical burn injuries can impede clarity of the cornea and cause vision impairment. Transforming growth factor b (TGFb) signaling pathway is known to mediate fibrotic scarring, and NADPH oxidase–derived reactive oxygen species has been shown to be an effector molecule that facilitates TGFb1-mediated responses. The present study explores the expression profile and functional importance of NADPH oxidase (Nox) in conjunctival fibroblasts. In addition, the effect of curcumin on the TGFb1induced NADPH oxidase expression and collagen synthesis was also investigated.
منابع مشابه
Transforming Growth Factor β1-Induced NADPH Oxidase-4 Expression and Fibrotic Response in Conjunctival Fibroblasts.
Purpose Fibrotic scarring after ocular surgeries and chemical burn injuries can impede clarity of the cornea and cause vision impairment. Transforming growth factor β (TGFβ) signaling pathway is known to mediate fibrotic scarring, and NADPH oxidase-derived reactive oxygen species has been shown to be an effector molecule that facilitates TGFβ1-mediated responses. The present study explores the ...
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تاریخ انتشار 2017